Real Madrid now have a 15-point gap with second-placed Barcelona.
The Los Blancos are currently sitting at the top of the table, 15 points clear of Barcelona, Sevilla and Atletico Madrid.
They have six remaining games in the league and could be crowned as early as this weekend if the midweek results go their way against Osasuna.
Both Luka Modric and Casemiro will not be available due to tiredness and minor injury but Benzema is expected to continue his excellent goalscoring run.
“It’s true that we’re close to winning the league, but we still have games to play,” Ancelotti said in a news conference on Tuesday. “I have too much experience to [feel like a champion]. It’s true that we’re very close and we’re doing well. But it isn’t over yet. Tomorrow is a great opportunity to get closer.”
“The count we do is quite simple,” Ancelotti added. “It’s getting three points against Osasuna, then getting three points against Espanyol, and if we need more, getting three points against Atletico. I’m not a mathematician, I prefer history.”